Professional Development

Applications

University

Assessment

The assessment for this module is designed to test the breadth and depth of your knowledge, as well as your ability to analyse, synthesize and summarise information critically, including published research.

The controlled component is a written exam. The exam will be 3 hours duration and allows you to demonstrate both your ability to research, prioritise information and produce a structured, evidence-based answer. This assessment links directly to requests from employers as they require graduates proficient at researching and scientific writing under pressure.

The case study provides the opportunity for you to complete an in-depth analysis of selected topic from the module syllabus by critically reviewing published research. The second assignment will be a problem-based data interpretation that allows you to select and use appropriate bioinformatics techniques and interpret the outputs of your
analysis.

Campus

Frenchay

Careers/further study

This module can contribute towards:

• BSc(Hons) Biological Science
• BSc(Hons) Biomedical Sciences (Clinical) Block Release Route
• BSc(Hons) Biomedical Sciences (including Clinical)
• BSc (Hons) Forensic Science
• BSc (Hons) Healthcare Science (Life Sciences).

Content

The module syllabus will cover:

Genome technologies

• DNA sequencing structure of a genome, Sanger sequencing, next generation sequencing, future sequencing technologies.
• Bioinfomatics Analysis Techniques - DNA gene annotation, DNA and proteindatabases, SRS. Pairwise alignment techniques; BLAST, identity and similarity.
• Multiple sequence alignment; PSI-BLAST, Clustal.
• Bioinformatics Analysis Techniques - Protein Secondary databases and proteinstructure predication; motifs, pattern and profile database, PROSITE, structuredatabases, Domains, ExPASy Proteomics tools.
• Structural Proteomics,methods of determination, how to display and store.
• Model Genomes Structure and organisation, techniques used to study mode genome, discoveries made.
• Analysis of gene expression and function expression analysis, microarrays, SAGE, RNAseq, functional assays, 'knock-out' and 'knock-down' echnologies, proteomics.

Applications of genome technologies

• Drug development and targets - analysis of drug resistance
• Identification of tumour-rejection antigens
• Genome Analysis in Forensic Science
• Reconstructing Phylogenies
• Antibiotic drug discovery and reverse vaccinology.

Course Director

Dr Dann Turner

E-mail

pd@uwe.ac.uk

Entry Requirements

Pre-requisites for this module includes one of the following;

• Molecular Biology (USSKAL-30-2)
• Genes and Biotechnology (USSKAM-30-2)
• Molecular Genetics (USSKB7-15-2).

Introduction

On successful completion of this module, you will be able to:

• Describe and critically discuss past, current and future developments in DNA sequencing technologies;
• Review and discuss the scope of bioinformatics including alignment techniques and databases.
• Select and use appropriate bioinformatic 'tools';
• Discuss the concept of 'model' genomes and their importance.
• Describe and critically assess the techniques used to analysis model genomes and the discoveries that have been made using them;

Learning and Teaching

The module will be delivered as mix of lectures and data analysis tutorials.

Study facilities

Find out more about UWE Bristol's facilities and resources.

Telephone

+44 (0)117 32 81158

You can also follow us on Twitter @UWEhasCPD.